Journal of Engineering in Industrial Research

h-index: 18     i10-index: 25

A Basic Strategic Approach for Method Development by Inductively Coupled Plasma Mass Spectrometry (ICP-MS): A Review

Document Type : Review Article

Authors

Amitkumar J. Vyas 1
Nensi D. Santoki 1
Dhruvi U. Parmar 1
Ajay I. Patel 1
Ashvin V. Dudhrejiya 1
Sunny R. Shah 2
Devang B. Sheth 3

1 Department of Pharmaceutical Quality Assurance, B. K. Mody Government Pharmacy College, Rajkot, Gujarat, India

2 Department of Pharmaceutics, Government Pharmacy College, Gandhinagar, Gujarat, India

3 Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat, India

https://doi.org/10.48309/jeires.2024.5.4
Abstract
Method development for ICP-MS entails optimizing parameters to ensure precise and accurate elemental measurements. Sample preparation involves selecting techniques like digestion and dilution. Instrument setup optimizes plasma power and calibration with certified reference materials. Mass selection considers sensitivity and interference. Background correction methods account for spectral interferences. Internal standards correct for variations. Quality control ensures accuracy through replicate analyses and spike recoveries. Data analysis involves quantification and validation based on regulatory guidelines. Method optimization refines parameters for improved sensitivity and robustness. Comprehensive documentation and SOPs maintain consistency. Validation assesses accuracy, precision, and linearity according to standards like USP and ICH. Overall, this systematic approach guarantees reliable elemental analysis using ICP-MS.

Keywords

Inductive coupled plasma
Method development
Standardization

OPEN ACCESS

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Journal of Engineering in Industrial Research
Volume 5, Issue 1
Winter 2024
Pages 42-51

  • Receive Date 01 May 2024
  • Revise Date 30 May 2024
  • Accept Date 20 June 2024

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